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LIST OF INITIATIVES

We are conducting research on the political, economic, scientific and organizational factors required to implement alternative business models of pharmaceutical research and development (R&D) that may better serve the global public interest (e.g., deliver both innovation and global access). 

As part of this research, we have created this database of initiatives that appear to fund, implement or facilitate pharmaceutical R&D in a manner that differs from the traditional business model. If you want to read the analysis of the database, you can find it here. If you want to download the database, you can do it here, and to download the data collection process, click here.

This database was updated in April 2024 with 8 additional alternative initiatives.

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Instituto Finlay de Vacunas (IFV)

Year or creation:

1991

Region (HQ):

Latin America and the Caribbean

Country (HQ):

Cuba

Active as of 12/2022:

Yes

Organizational form:

National government agencies

Technology Type:

Vaccines

Disease Area:

Infectious diseases prevalent in Cuba, Infectious diseases

The Finlay Vaccine Institute’s mission is to “investigate, develop, produce, evaluate, negotiate and commercialize knowledge, technologies and products, especially vaccines; directing all its technological, human and financial resources in pursuit of promoting the Advanced Vaccine Program, economic growth and development and the quality of life of the Cuban population” (The Finlay Vaccine Institute, n.d.).

International Centre for Genetic Engineering and Biotechnology (ICGEB)

Year or creation:

1983

Region (HQ):

Western Europe

Country (HQ):

Italy

Active as of 12/2022:

Yes

Organizational form:

Intergovernmental Organization

Technology Type:

Vaccines, Therapeutics, Basic science

Disease Area:

Not disease-specific

“The ICGEB is a unique intergovernmental organisation initially established as a special project of UNIDO. Autonomous since 1994, it runs over 45 state-of-the-art laboratories, in Trieste, Italy, New Delhi, India and Cape Town, South Africa and forms an interactive network with almost 70 Member States, with operations aligned to those of the United Nations System. It plays a key role in Biotechnology promoting Research excellence, Training, and Technology Transfer to industry, to contribute in concrete terms to sustainable global development” (ICGEB, n.d.).

International Vaccine Institute (IVI)

Year or creation:

1996

Region (HQ):

East Asia and Pacific

Country (HQ):

Republic of Korea

Active as of 12/2022:

Yes

Organizational form:

Intergovernmental Organization

Technology Type:

Vaccines

Disease Area:

Cholera, Typhoid, Dengue, MERS, Schistosomiasis, Chikungunya, COVID-19

“The International Vaccine Institute (IVI) is a nonprofit International Organization established in 1997 as an initiative of the United Nations Development Programme (UNDP). We are among the few organizations in the world dedicated to vaccines and vaccination for global health. Our mission: Discover, develop and deliver safe, effective and affordable vaccines for global public health. IVI is headquartered in Seoul and hosted by the Republic of Korea with 39 member countries and the WHO on its treaty” (IVI, n.d.).

Justus-Liebig-Universität Gießen

Year or creation:

Unclear

Region (HQ):

Western Europe

Country (HQ):

Germany

Active as of 12/2022:

Yes

Organizational form:

Academic and other research institutions

Technology Type:

Not specified

Disease Area:

Neglected diseases

This organization was included for its participation in non profit R&D for Neglected Diseases (Vieira M, Kimmitt R and Moon S.  F1000Research 2021, 10:190)

Longitude Prize

Year or creation:

2014

Region (HQ):

Western Europe

Country (HQ):

United Kingdom

Active as of 12/2022:

Yes

Organizational form:

Private Company

Technology Type:

Diagnostics

Disease Area:

Bacterial diseases

“The Longitude Prize is looking for a team of innovators from anywhere in the world to invent an affordable, accurate, fast and easy-to-use test for bacterial infections that will allow health professionals worldwide to administer the right antibiotics at the right time. £8 million will be awarded to the winner, to help tackle the global problem of antibiotic resistance…Delivered day-to-day by Challenge Works, the prize is supported by a committee of experts from across the scientific, clinical and industrial world” (Longitude Prize, n.d.).

This initiative was selected based on its inclusion in the report “RE:ROUTE, A map of the alternative biomedical R&D landscape”, (Kiddell-Monroe, Greenberg, and Basey 2016).

McGill University

Year or creation:

Unclear

Region (HQ):

North America

Country (HQ):

Canada

Active as of 12/2022:

Yes

Organizational form:

Academic and other research institutions

Technology Type:

Not specified

Disease Area:

Neglected diseases

This organization was included for its participation in non profit R&D for Neglected Diseases (Vieira M, Kimmitt R and Moon S.  F1000Research 2021, 10:190)

International AIDS Vaccine Initiative (IAVI)

Year or creation:

1996

Region (HQ):

North America

Country (HQ):

United States

Active as of 12/2022:

Yes

Organizational form:

Not-for-profit organization

Technology Type:

Vaccines

Disease Area:

HIV, Lassa fever, Marburg virus disease, Sudan ebolavirus disease, Tuberculosis, Infectious diseases, COVID-19

“IAVI is a nonprofit scientific research organization that develops vaccines and antibodies for HIV, tuberculosis, emerging infectious diseases (including COVID-19), and neglected diseases. Our mission is to translate scientific discoveries into affordable, globally accessible public health solutions…IAVI accelerates scientific discovery and development by fostering unique collaborations among academia, industry, local communities, governments, and funders to explore new and better ways to address public health threats that disproportionately affect people living in poverty” (IAVI, n.d.).

International Partnership for Microbicides (IPM)

Year or creation:

2002

Region (HQ):

North America

Country (HQ):

United States

Active as of 12/2022:

Yes

Organizational form:

Not-for-profit organization

Technology Type:

Microbicides

Disease Area:

HIV, Sexual and Reproductive Health

“IPM is dedicated to providing women with affordable and self-initiated HIV-prevention strategies they can use to protect their own health. Founded in 2002 as a product development partnership (PDP), IPM has become an important partner in the microbicide field. Since our inception, IPM has focused our efforts on developing antiretroviral (ARV)-based microbicides in collaboration with our partners…IPM also engages and collaborates with advocates and global health leaders to raise awareness about microbicides and HIV prevention products worldwide. Through our working partnerships at the local and national level in developing countries, IPM has helped build health research infrastructure in parts of the world where the need for health research is greatest” (IPM, n.d.).

Just – Evotec Biologics

Year or creation:

2014

Region (HQ):

North America

Country (HQ):

United States

Active as of 12/2022:

Yes

Organizational form:

Publicly Traded Company

Technology Type:

Therapeutics

Disease Area:

Production of biotherapeutics

“Just Biotherapeutics was founded in 2014 by an experienced team spanning the fields of protein, process and manufacturing sciences to help complete a mission that began in the early 1980’s. This mission has been to solve the scientific and technical hurdles blocking access to life changing protein therapeutics…In 2019, Just joined forces with Evotec SE and now, as a combined organization, “Just – Evotec Biologics” is creating global access through evolutionary technology. Connecting the Just biologics platform “J.DESIGN” with the strong therapeutic and preclinical biology of Evotec creates a powerful, integrated approach to biotherapeutics” (Just – Evotec Biologics, n.d.).

Kaggle

Year or creation:

2010

Region (HQ):

North America

Country (HQ):

United States

Active as of 12/2022:

Unclear

Organizational form:

Private Company

Technology Type:

Not specified

Disease Area:

Not disease-specific

Kaggle is “an online platform for data-mining and predictive modeling competitions” (Goetz, 2013). “[Participants] compete to solve complex data science problems. Kaggle is free to all data scientists; [the] fees are paid by the owner of the data problem” (Kaggle, 2015).

This initiative was selected based on its inclusion in the report “RE:ROUTE, A map of the alternative biomedical R&D landscape”, (Kiddell-Monroe, Greenberg, and Basey 2016)

M4K Pharma

Year or creation:

2017

Region (HQ):

North America

Country (HQ):

Canada

Active as of 12/2022:

Yes

Organizational form:

Private Company

Technology Type:

Therapeutics

Disease Area:

Rare diseases - Paediatric

M4K Pharma’s mission is to “use open science to revolutionize how affordable new treatments are discovered and developed. By aggregating and aligning the work of global academics, foundations and pharma/biotech researchers, we will advance new cures for childhood diseases not well served by current business models…We believe that open science can lead to affordable medicines by fostering collaborations and accelerating medical discoveries. We are committed to sharing the scientific knowledge derived from our programs and will not limit access to our research by filing patents. We will encourage and assist our partners to publish and disseminate their research widely” (M4K Pharma, n.d.).

Medicines Development for Global Health (MDGH)

Year or creation:

2005

Region (HQ):

Oceania

Country (HQ):

Australia

Active as of 12/2022:

Yes

Organizational form:

Not-for-profit organization

Technology Type:

Therapeutics

Disease Area:

Neglected diseases

“Medicines Development for Global Health (MDGH) is an independent not-for-profit company dedicated to the development of medicines for those who need them most. We address health inequity by researching, developing and delivering new and improved medicines for diseases disproportionately affecting low- and middle-income countries. MDGH was founded by Mark Sullivan in 2005. Since then, we have demonstrated that we can assemble the resources, collaborators and financing required to develop and register new medicines for infectious diseases” (MDGH, n.d.).

The development of this database is the result of the collective effort of the NBM research team members: Suerie Moon, Adrián Alonso Ruiz, Marcela Vieira, Kaitlin Large, Iulia Slovenski, Yiqi Liu, Danielle Navarro, Temmy Sunyoto and Surabhi Agarwal.

 

This website was developed by Bétina Zago and Adrián Alonso Ruiz, with the supervision of Suerie Moon, and the support of Marcela Vieira, Kaitlin Large, Iulia Slovenski and Yiqi Liu.

 

This work was supported by a Swiss National Science Foundation PRIMA Grant (179842). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

ABOUT US

 

The Knowledge Network on Innovation and Access to Medicines is a project of the Global Health Centre at the Graduate Institute, Geneva. The project seeks to maximize the contributions of research and analysis to producing public health needs-driven innovation and globally-equitable access to medicines.

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